Placebo control
SH60 and SH120 groups are compared with a placebo group.
Evidence base
Research
Scientific basis and research results of the key components of the formula.
Skin, hydration, and collagen
05
Research 01
Effects of Oral Hyaluronic Acid Intake on Skin Hydration and Transepidermal Water Loss
3 months
Objective
To evaluate the effect of two doses of hyaluronic acid on skin hydration and reduction of TEWL (transepidermal water loss) with oral administration.
Duration
3 months
Participants
150 volunteers (women and men, 18–60 years), SH60, SH120 and placebo groups
Parameters
- Hydration (Corneometer)
- TEWL (Tewameter)
Actual results
After 3 months, cheek skin hydration in the 60 mg group was 9.1% higher than in the placebo group, forehead — 8.7% higher. Transepidermal water loss decreased significantly versus placebo — the skin barrier function was strengthened.
Research 02
Effect of oral hyaluronic acid on skin structure, wrinkles and dermal collagen
3 months
Objective
To investigate the effect of daily hyaluronic acid intake on wrinkle depth, dermal collagen level and natural moisturising factor (NMF) content in the stratum corneum.
Duration
3 months
Participants
150 volunteers (women and men, 18–60 years), SH60, SH120 and placebo groups
Parameters
- Wrinkle depth (Primos 3D)
- Collagen — dermal density (Ultrascan)
- NMF (tape stripping, UHPLC-MS/MS)
Actual results
Periorbital wrinkle depth in the 60 mg group decreased significantly versus placebo as early as one month into supplementation.
Research 03
Comprehensive Skin Improvement Following Nutrihyl® Intake: A Double-Blind Placebo-Controlled Study
3 months
Objective
To assess the overall effect of daily Nutrihyl® intake on the skin: sebum, redness and participants’ perception of changes in skin condition.
Duration
3 months
Participants
150 volunteers (women and men, 18–60 years), SH60, SH120 and placebo groups
Parameters
- Sebum (Sebumeter)
- Redness (VisiaCR)
- Questionnaires: hydration, oiliness, wrinkles, sensitivity
Actual results
In questionnaires, participants in the 60 mg group rated their skin as less oily and with slightly fewer and shallower wrinkles than the placebo group.
Research 04
Oral Hyaluronic Acid: improving skin hydration, reducing wrinkles and increasing elasticity
40 days
Objective
To evaluate the efficacy of daily oral administration of biotechnologically produced hyaluronic acid (approx. 1 MDa) in combination with biotin, vitamin C, zinc, copper, and silicon on skin condition in middle-aged women.
Duration
40 days
Participants
20 women aged 45–60, open-label study without a placebo group
Parameters
- Skin elasticity
- Surface roughness
- Condition of hair and nails
Actual results
Already after 20 days, a statistically significant improvement in all main parameters was recorded: skin hydration increased by 21.6% (to 24.4% at day 40), elasticity rose by 8.6% (to 13.3%), roughness decreased by 12.7% (to 16.9%), and wrinkle depth was reduced by 26.4% over 40 days (measured in 6 participants). About 50% of participants reported improved hair and nails. No side effects were recorded.
Research 05
High molecular weight hyaluronic acid: improves skin hydration, tone, and texture
12 weeks
Objective
Evaluate the efficacy of daily oral administration of hyaluronic acid with a molecular weight of 300 kDa at different doses (100 mg and 200 mg per day) on skin condition in women of various ages and skin types.
Duration
12 weeks
Participants
129 women (61 aged 18–35, 67 aged 45–65), dry, normal or oily skin
Parameters
- Evenness of tone
- Epidermal thickness
- Wrinkle photoanalysis
- Overall skin condition
Actual results
Within 2–8 weeks, skin hydration increased significantly compared with baseline in both the younger and the older group. Skin tone improved (less yellowness) after 4–8 weeks, and epidermal thickness increased after 12 weeks.
Standards of proof
How the main study was conducted
Double-blind study
Neither participants nor researchers know the assignment until completion.
Instrumental measurements
Corneometer, Tewameter, Primos 3D, Ultrascan, Sebumeter, VisiaCR.
Peer-reviewed journal
Scientific Reports (Nature Portfolio).
Evidence base
From research to your daily serving
L'AURON Freeze Age contains 120 mg of hyaluronic acid, featuring Nutrihyl® — the form studied in the Contipro research above.
Buy L'AURON Freeze AgeSources and Regulatory Information
¹ Dolečková I. et al., Scientific Reports, 2026; 16:2941.
⁴ Göllner I. et al., J Evid Based Complementary Altern Med. 2017;22(4):816–823. PMC ID: PMC5871318.
⁵ Gao Y.-R. et al., Skin Res Technol. 2023;29(11):e13531. PMC ID: PMC10661223.
The studies presented relate to hyaluronic acid as an ingredient, not a finished product. Dietary supplement, not a medicinal product. Food supplements complement a daily diet and a healthy lifestyle. Consume in accordance with the recommended daily dose. It is advisable to consult a doctor before use. Not recommended for children and adolescents under 18 years of age, as well as pregnant and breastfeeding women.